Hydatidiform mole

Signs and symptoms[ edit ] Vesicular mole Molar pregnancies usually present with painless vaginal bleeding in the fourth to fifth months of pregnancy.

Hydatidiform mole

Request an Appointment at Mayo Clinic Causes A molar pregnancy is caused by an abnormally fertilized egg. Human cells normally contain 23 pairs of chromosomes.

One chromosome in each pair comes from the father, the other from the mother. In a complete molar pregnancy, an empty egg is fertilized by one or two sperm, and all of the genetic material is from the father. In this situation, the chromosomes from the mother's egg are lost or inactivated and the father's chromosomes are duplicated.

In a partial or incomplete molar pregnancy, the mother's chromosomes remain but the father provides two sets of chromosomes. As a result, the embryo has 69 chromosomes instead of This most often occurs when two sperm fertilize an egg, resulting in an extra copy of the father's genetic material.

Risk factors Approximately 1 in every 1, Hydatidiform mole is diagnosed as a molar pregnancy. Various factors are associated with molar pregnancy, including: A molar pregnancy is more likely in women older than age 35 or younger than age If you've had one molar pregnancy, you're more likely to have another.

A repeat molar pregnancy happens, on average, in 1 out of every women.

Pathology Atlas: Gestational Trophoblastic Disease

Complications After a molar pregnancy has been removed, molar tissue may remain and continue to grow. This is called persistent gestational trophoblastic neoplasia GTN. This occurs in approximately 15 to 20 percent of complete molar pregnancies, and up to 5 percent of partial molar pregnancies.

One sign of persistent GTN is a high level of human chorionic gonadotropin HCG — a pregnancy hormone — after the molar pregnancy has been removed. In some cases, an invasive hydatidiform mole penetrates deep into the middle layer of the uterine wall, which causes vaginal bleeding.

Persistent GTN can nearly always be successfully treated, most often with chemotherapy. Another treatment option is removal of the uterus hysterectomy. Rarely, a cancerous form of GTN known as choriocarcinoma develops and spreads to other organs.

Choriocarcinoma is usually successfully treated with multiple cancer drugs. A complete molar pregnancy is more likely to have this complication than a partial molar pregnancy.

Prevention If you've had a molar pregnancy, talk to your doctor or pregnancy care provider before conceiving again. He or she may recommend waiting for six months to one year before trying to become pregnant.

The risk of recurrence is low, but higher than the risk for women with no previous history of molar pregnancy. During any subsequent pregnancies, your care provider may do early ultrasounds to monitor your condition and offer reassurance of normal development.

Hydatidiform mole

Your provider may also discuss prenatal genetic testing, which can be used to diagnose a molar pregnancy.Another type of abnormality is when only the conceptus trophoblast layers proliferates and not the embryoblast, no embryo develops, this is called a "hydatidiform mole", which is due to the continuing presence of the trophoblastic layer, this abnormal conceptus can also implant in the uterus.

Two patients with hydatidiform mole had severe hyperthyroidism, and pulmonary edema developed. The thyrotoxicosis improved rapidly after evacuation of the mole.

Know the symptoms

A thyroid stimulator was extracted. Molar pregnancy is an unusual and severe complication of pregnancy. Medically referred to as hydatidiform mole, it is a type of gestational trophoblastic disease (GTD). The article throws light on the symptoms and treatment of such a pregnancy.

Gestational trophoblastic disease is the degeneration and abnormal proliferation of the trophoblastic villi. The cells become filled with clear fluid, giving them the appearance of grape-like vesicles. Neoplasia (tumors) are abnormal tissue proliferations, which develop exceeding normal tissue, uncoordinated with it.

This uncontrolled tissue growing may continue even after cessation of the etiologic factor (self-maintained). The structure of a tumor (neoplasia): parenchyma (tumor cells derived from previously normal cells) and stroma (vessels and connective tissue), in variable proportions.

Discharge Instructions for Hydatidiform Mole. You have been diagnosed with a hydatidiform mole (also called molar pregnancy). A hydatidiform mole is the overgrowth of tissue surrounding a .

Hydatidiform mole | definition of hydatidiform mole by Medical dictionary